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William R Heineman


Bill Heineman

University Distinguished Research Professor


Professor, Chemistry

PhD, University of North Carolina at Chapel Hill, 1968

Biography

William R. Heineman received a BS degree in Chemistry from Texas Tech University in 1964 and a PhD in 1968 in Analytical Chemistry from the University of North Carolina at Chapel Hill, where he worked under the direction of Professor Royce Murray. He was a Research Chemist at Hercules Research Center for two years before becoming a Postdoctoral Research Associate with Professor Ted Kuwana in 1970 at Case Western Reserve University and then at The Ohio State University. He joined the faculty at the University of Cincinnati in 1972 where he is now Distinguished Research Professor. Professor Heineman?s research interests include spectroelectrochemistry, chemical sensors, analytical chemistry of radiopharmaceuticals, polymer modified electrodes, electrochemical immunoassay, and microfluidic systems for chemical analysis. He has published over 300 research papers and patents and has presented over 500 lectures at conferences, universities, and government/industrial laboratories. He is coauthor of the laboratory manual Chemical Experiments for Instrumental Methods, the instrumental analysis textbook Chemical Instrumentation: A Systematic Approach; and coeditor of the textbook Laboratory Techniques in Electroanalytical Chemistry. Professor Heineman has received the following awards: Sigma Xi Research Recognition Award, Cincinnati Chemist of the Year, Distinguished Scientist Award from the Technical Societies Council of the Engineers and Scientists of Cincinnati, Japan Society for the Promotion of Science Fellowship, Japanese Government Research Award for Foreign Scientists, George Rieveschl, Jr. Award for Distinguished Scientific Research, Humboldt Prize from West Germany, McMicken Dean's Award for Distinguished Scholarship, Hans H. Jaffe Chemistry Award, Charles N. Reilley Award in Electroanalytical Chemistry from the Society for Electroanalytical Chemistry, Chemical Sensors Award from the International Meeting on Chemical Sensors, Award for Excellence in Teaching from the Division of Analytical Chemistry of the American Chemical Society, Torbern Bergman Medal 1999 from the Analytical Section of the Swedish Chemical Society. He was elected a Fellow of the American Association for the Advancement of Science in 2001. He will be awarded the 2003 "Fields of Analytical" award given by the Eastern Analytical Association, which is given only to those analytical chemists who have achieved distinction in several differing sub-fields of analytical chemistry. Professor Heineman is a member of the advisory boards of Biosensors and Bioelectronics, Electroanalysis, Analytical Sciences, and Applied Biochemistry and Biotechnology, and is a past member of the advisory boards of Analytical Chemistry, Analytica Chimica Acta, The Analyst, Selective Electrode Reviews, Quimica Analitica, and Fresenius Journal of Analytical Chemistry. He was chairman of two Gordon Research Conferences: Electrochemistry and Analytical Chemistry. Professor Heineman was a co-founder and the first President of the Society for Electroanalytical Chemistry and was a member of the Board of Directors. He has been active in the American Chemical Society for a number of years. In the Cincinnati Section he served as Chair, Trustee, and Councilor. In the Division of Analytical Chemistry he has served as Treasurer, Councilor, and Chair.

Research: Analytical Chemistry

  • Spectroelectrochemistry
  • Chemical sensors & biosensors
  • Polymer modified electrodes
  • Electrochemical immunoassay
  • Microfluidic systems for chemical analysis


My research interests are primarily in sensors, electroanalytical chemistry, and bioanalytical chemistry. Many of the projects are interdisciplinary and involve collaborations with other groups in chemistry, engineering, medical sciences, industry, government labs, and other universities.

Novel spectroelectrochemical sensor A novel sensor with remarkable selectivity has been developed by combining partitioning into a film, electrochemistry, and spectroscopy in a single device. The sensor is based on multiple internal reflection at an optically transparent electrode (OTE). The OTE is coated with a thin chemically-selective film that serves to enhance detection limit by preconcentrating the analyte. The evanescent field at the points of internal reflection penetrates the film so that electrochemistry within the film can be monitored optically. Project areas include new selective films, strategies for detecting analytes with poor optical properties, instrumentation, theory, and applications such as sensors for nuclear waste and polycyclic aromatic hydrocarbons in the environment.

.Biosensors Biosensors use selective biological recognition reactions to target a specific analyte. We have made significant contributions to the development of electrochemical immunosensors where the biological recognition element is an antibody. Projects include immunoassay based on capture antibody immobilized on paramagnetic microbeads, immunoassay on a microfabricated chip (i.e., a laboratory on a chip), and electrochemical detection with interdigitated array microelectrodes and carbon nanotubes. Application areas include detection of herbicides, pesticides, toxins, viruses and bacteria in water; the analysis of samples of medical importance such as from neonates and the elderly where sample size is limited; and forensic analysis where the amount of sample available for analysis can also be extremely small.

Capillary electrophoresis on a microchip A goal of this research is to significantly improve the determination of trace amounts of biologicals with respect to speed of analysis, selectivity, and limit of detection, versus the standard methodology. Aptamer-based assays of polypeptides and proteins are used as illustrative chemical systems. Affinity capillary electrophoresis on a multilane plastic microchip with detection by laser induced fluorescence is the analytical technique.


Contact Information
120 Crosley
P.O. Box 210172
Cincinnati, OH 45221-0172
phone: 513-556-9210
fax: 513-556-9239
heinemwr@uc.edu
http://www.che.uc.edu/sensors/index.html


Last updated Friday, September 15, 2006

 


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