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H Brian Halsall
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Professor, Chemistry
BSc University of Birmingham, England, 1964
PhD University of Birmingham, England, 1967
Postdoctoral Scholar, UCLA, 1967-1969
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BiographyBrian Halsall has had broad research interests in analytical and physical biochemistry since his PhD work with Peter Spragg on analytical ultracentrifugation and its application to studying glycoprotein aggregation. His postdoctoral studies with Verne Schumaker at UCLA explored the analytical aspects of the zonal ultracentrifuge, and these he continued while on the staff of the MAN program, directed by Norman Anderson, at Oak Ridge National Laboratory. He joined the Chemistry Department of the University of Cincinnati in 1974 where he has revisited glycoprotein biochemistry and moved into high sensitivity biosensors.
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Research: Biochemistry
- Immuno and biosensors
- Immunoassay with electrochemical detection
- Well-defined surfaces for hosting macromolecular interactions
- Immunoassay and blood substitutes
- Drug-glycoprotein interactions
- Glycoprotein structure and stability
Our research involves bioanalysis in the broadest sense, and we have two main foci.
The first uses human orosomucoid (alpha1-acid glycoprotein) as a model to explore the function(s) of the glycan chains and the relationships that may exist between the protein core and the glycan chains covalently attached to it. For example, we have developed methodology that permits the investigation of disease/glycan chain correlations for each of the five individual glycosylation sites for both of the genes that code for orosomucoid. Most recently, we have begun to examine the role of molecular crowding on the structure and stability of orosomucoid.
Our second focus, as part of the Sensors Group, is in the related areas of sensing, immunoassay, and microfluidics. Here, we are developing immuno- and bio-sensors with fast response times, and capable of very low detection limits, for analytes such as pathogenic E coli and biowarfare agents in natural and processed waters. Related work includes the effects of chlorination on the analytes, minimizing interactions between biological and non-biological surfaces, label-free sensing, and the further development of a pathogen substitute, the Bugbead.
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Contact Information
803 Crosley
P.O. Box 210172
Cincinnati, OH 45221-0172
phone: 513-556-9274
fax: 513-556-9239
Brian.Halsall@uc.edu
http://www.che.uc.edu |
Last updated Friday, September 15, 2006
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