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Albert M. Bobst
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Professor, Chemistry
PhD, University of Zuerich Switzerland, 1965
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BiographyAlbert Bobst is Professor of Chemistry and Biological Chemistry at the University of Cincinnati. After receiving his PhD at the University of Zurich in 1965, where he characterized Tetrahydropterins by nuclear magnetic resonance, he spent a postdoctoral year in Paris at the Institut de Biologie Physico-Chimique with Professor Pullman studying Quantum Biochemistry. Subsequently he was awarded a Swiss National Science Fellowship to study under the guidance of Professor Calvin and Tinoco Photosynthesis and Nucleic Acid Chemistry at Berkeley, California. In 1968 he went to Princeton University as a Research Associate before joining the faculty at the University of Cincinnati in 1969. He was a visiting scientist at the National Institutes of Health in 1976 and 1984, and also at the ISREC in Lausanne, Switzerland in 1979.
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Research: The Chemistry of Nucleic Acids
Professor Bobst is pursuing investigations in the areas of the synthesis of nucleic acid analogs, oligonucleotide chemistry, enzymatic synthesis of nucleic acids, bioconjugate chemistry, and the detection of free radical damage in biological systems by electron paramagnetic resonance spectroscopy (EPR).
The synthesis studies are aimed at preparing novel nucleic acid derivatives and to conjugate small molecules such as spin labels (nitroxide radicals) with nucleic acids. His group has generated a variety of spin labeled nucleic acid building blocks which are incorporated either enzymatically into polynucleotides with nick translation or chemically into oligonucleotides with a gene assembler. The spin labeled nucleic acids are studied by EPR to get a better understanding of the structural and conformational properties of nucleic acids and nucleic acid- protein complexes. Molecular modeling is used to analyze long range distances derived from EPR spectra resulting from nitroxide - nitroxide interactions. Some of the spin labeled oligonucleotides are also used as molecular size sensors for detecting specific genes by EPR.
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Contact Information
903 Crosley
P.O. Box 210172
Cincinnati, OH 45221-0172
phone: 513-556-9281
fax: 513-556-9239
albert.bobst@uc.edu
http://www.che.uc.edu/bobst/Home.htm |
Last updated Friday, September 15, 2006
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