"The Strange Evolution of Gold Chemistry in Medicine"
Gold has been used medicinally from ancient times. Its "scientific" use dates from the late nineteenth century, when gold cyanide was used to treat tuberculosis. This substance was found to be rather toxic and so gold complexes with sulfur-containing ligands, such as sodium gold thiosulfate were adopted for treatment as well. Since then "gold salts" have been determined to unsatisfactory for the treatment of TB but have been important for the treatment of rheumatoid arthritis. In the past 20 years there has been a rebirth of interest in these material, with the development of an agent which can be taken orally and a considerable increase in our understanding of the chemistry and perhaps the mode of action of these materials. Recently gold containing pharmaceuticals have been proposed for the treatment of AIDS.
Richard C. Elder was trained as an inorganic chemist and crystallographer at MIT from which he received a Ph. D. in 1964. After 5 years at the University of Chicago he moved to the Department of Chemistry at the University of Cincinnati. After a sabbatical in Australia in 1977, he developed an interest in metal-based drugs and imaging agents. His background in crystallography has given him an unusual perspective in his current field of bio-inorganic chemistry of metal-based drugs and their metabolites. His collaborations with his wife (Katherine Tepperman) and many other colleagues have led him to not only implement several new techniques for identifying metal-based drugs but also new methods for determining molecular structure.
Mr. Edward R. Cox was born and raised in Dayton, Ohio and graduated from Northridge High School in 1982. Upon completing high school, Mr. Cox was awarded a Dow Chemical Company Scholarship to Wright State University. While in school, Mr. Cox was selected for a student job in the Materials Division at Wright Patterson Air Force Base. After graduating with a B.S. in Chemistry in 1986, Mr. Cox began working for a small electrochemical plating company in Dayton. In 1987, he left the electrochemical position to join the Oral Care research team for P & G at the Sharon Woods Technical Center. Mr. Cox currently still works in Oral Care in the global upstream technology division at the HCRC center in Mason where he uses a variety of analytical and biological methods to develop new products.
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Call the Section answering line at 576-3034 extension 6715 or send by Internet e-Mail to ashingd@basf.com giving your name (including spelling), your professional affiliation, and menu choice. Reservations are due by 12 noon, Friday, March 8, 1996. If difficulty is encountered, please call Deanna Ashing at 576-3124. Payment will be received at the door. Guests are always welcome; emeritus, unemployed, new, and student members are half price.
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HTML version prepared on February 26, 1996 by Jeffrey.Nauss@UC.Edu.