CINCINNATI SECTION AMERICAN CHEMICAL SOCIETY DECEMBER MEETING THURSDAY, DECEMBER 9, 1999

Program
 

5:30-6:30 PM	Organic Discussion Group: Dr. Michael Natchus  Heterocycle-Based MMP Inhibitors Room 9 Williams College of Business Administration
5:30-6:30	Board Meeting - Board Room, 2nd floor, University Center
6:00	SOCIAL HOUR - Terrace Room, 2nd floor, University Center Open Beer and Wine Bar
7:00	DINNER -Cost $15.00 (New members, unemployed members, students, K-12 teachers and emeritus members half price)
8:00	Dr. David Schutt, Assistant Director, ACS Office of Legislative and Government Affairs  Government Relations Within the American Chemical Society

BUFFET DINNER MENU INCLUDES:
Tossed Salad, Pasta Bar, Cheese Lasagna Spaghetti with Meat Sauce, Fettuccine with Alfredo Sauce, Italian Green Beans, Garlic Bread, Rum Cake, Soda, Coffee, Tea

Dinner Reservations:
Make your reservations by e-mail cintacs.im@pg.com   Include your name (complete with correct spelling), phone number and affiliation. Please specify if this is your first Cincinnati ACS meeting when making your reservation. All reservations must be received by noon, Monday, December 6. If you have any difficulties, please call Vicki Libbin at (513)622-2495. As a reminder, if you decide you must miss a meeting after you have made reservations, please call to cancel. If you do not cancel, the Section will have to charge you because it will have been charged by the hotel. Payment will be received at the door. Guests are always welcome; emeritus, unemployed, new, and student members are half price.

Directions:
From I-71. Exit at Dana Road Exit, take Dana Road west to Xavier University. The entrance to the parking area is to your right just before you come to Victory Parkway. YOU MUST USE THE PARKING PASS!

From I-75. Exit at Mitchell Road, take Mitchell Road east, name will change to Dana Avenue approximately 1/4 mile after crossing Reading Road. Continue past Victory Parkway. The entrance to the parking area in on you left about half a block after Victory Parkway. YOU MUST USE THE PARKING PASS!

While some have argued that science and politics do not, or least should not mix, the reality is that they are inextricably intertwined. Policymakers have long recognized the important contributions of science and technology to national security, improved health, and a robust economy. It is this recognition that has led to the federal government's generous support of R&D and its significant emphasis on science and mathematics education. In fact, the role of science in public policy decision-making will take on increasing importance in the next decade as we tackle even more challenging social issues, such as biotechnology and the environment. As a congressionally chartered organization, the American Chemical Society has embraced its responsibility to work with federal and state governments to ensure that public policy is based on sound science, and that public policy promotes the advancement of science and enhances the scientist's ability to contribute to national and human welfare. Dr. Schutt will provide anoverview of the public policy activities of the American Chemical Society, as well as describe opportunities for members of the local section to contribute to and participate in the public policy process.

Dr. David L. Schutt is an Assistant Director at the American Chemical Society. He oversees the Office of Legislative and Government Affairs, which has responsibility for the public policy activities of the Society at the federal, state, and local levels of government. The Office serves as a liaison between scientists and the government by ensuring that public policy is based in sound science and that the interest of scientists are adequately represented within government. Additionally, Dr. Schutt works with the Office of the Executive Director as a consultant in the Society's strategic planning process. Dr. Schutt is a physical chemist, having received his doctorate in chemistry from Princeton University and his bachelor's degree from Calvin College. He also has earned an MBA from Johns Hopkins University.

The overexpression of matrix metalloproteinase enzymes (MMPs) has been implicated in the disease process for a number of pathological conditions including arthritis, tumor metastases, multiple sclerosis, reprofusion injury and other conditions where tissue degredation plays a key role. The development of inhibitors for these enzymes have thus become the focus of many research groups throughout industry and academia. The approach which will be described here was developed by partnering a focused traditional medicinal chemistry program with the aid of modern rational design techniques. These methods will be highlighted in a discussion which describes a program where peptidomimetic inhibitors of type A were transformed into much more efficaceous heterocyclic inhibitors of type B. Subtopics within this presentation will include synthetic design and execution, SAR, pharmacokinetics and in-vivo efficacy.

Mike Natchus received his Ph.D. degree in 1992 in organic synthesis from VA Tech under the guidance of Prof. Tomes Hudlicky. While there, he completed the total synthesis of numerous natural products and helped develop new methods for asymmetric induction using biocatalytic techniques. He also spent 2 years doing custom synthesis with TDC Research. From there, he went to Stanford University to do post doctoral studies under the direction of Paul Wender. While there, he worked on the total synthesis of the anti-tumor agent Taxol. Afterward in 1994, he returned to VA Tech where he was a visiting professor for one semester. He then went on to Procter and Gamble Pharmaceuticals in 1994 where he has since been developing inhibitors for the matrix metalloproteinases to be used as medicinal agents for osteoarthritis.

Updated 19 November 1999 by cinacs@www.che.uc.edu