Schedule of events:
 

5:30-6:30	DISCUSSION GROUPS
	Biochemistry - Room 101 Linder Hall (Physics Building)  Dr. Daniel Hassett, University of Cincinnati "Role of Quorum Sensing (bacteria talking) in the Control of Oxidative Stress Genes in Pseudomonas aeruginosa"
	Chemical Information - Room 1 Williams College of Business Edlyn Simmons, Hoechst Marion Roussel, Inc. "Chemical Information: How to Find the 70% That is Only in Patents"
	Board Meeting - President’s Board Room, 3rd floor, University Center
6:00	SOCIAL HOUR - Terrace Room, 3rd floor, University Center
7:00	DINNER - Cost $16.00 Buffet Dinner Includes: Tossed Salad, Pasta Bar (Cheese Lasagna, Spaghetti with Meat Sauce, Fettuccine with Alfredo Sauce), Italian Green Beans, Garlic Bread, Rum Cake, Soda, Coffee, Tea, Beer and Wine
	.
8:00	SPEAKER: Milton Zmijewski Solving Chemical Problems using Fermentations and Enzymes or Going over to the Dark Side

Dinner reservations: Call the section answering line at 558-1224 or email cintacs@uc.edu. Include your name with correct spelling, affiliation, and menu choice. Reservations must be received by Monday, November 30 at 10:00 AM. If you have any difficulties, please call Donna Taylor at 558-0979. As a reminder, if you decide you must miss a meeting after you have made reservations, please call to cancel. If not, the section will have to charge you for the dinner because it will be charged for the dinner.

Directions: From I-71. Exit at Dana Road Exit, take Dana Road west to Xavier University. The entrance to the parking area is to your right just before you come to Victory Parkway. From I-75. Exit at Mitchell Road, take Mitchell Road east, name will change to Dana Avenue approximately 1/4 mile after crossing Reading Road. Continue past Victory Parkway. The entrance to the parking area in on you left about half a block after Victory Parkway.

Synthetic organic chemists are oriented toward the synthesis of large complex natural products using long synthetic schemes. In many cases, this is as close to biology as most organic chemists come. The use of fermentation microbiology and enzymes to solve chemical problems is still in its infancy in the USA. This is largely due to the chemists’ resistance in adopting these methods via collaborations or self teaching. In the first part of the lecture, we will discuss the general principles of fermentations and enzymes. This part of the presentation will align the chemical mind toward the dark side (biology). The remainder of the lecture will consist of examples where biology has allowed very difficult chemistry to be performed or has allowed for a dramatic reduction in industrial waste. Here examples from beta-lactam chemistry and the chemistry of a central nervous system acting compound will show just how effective an interdisciplinary approach can be to solving large scale industrial problems. These same principles can be used and applied to laboratory syntheses only if the chemist will cross over to the dark side.

Milton Zmijewski received a B.S. degree in biology from Mount St. Mary’s College and a M.S. degree in microbiology from the University of Maryland. After receiving a Ph.D. in pharmaceutical sciences from the University of Kentucky, he did a post-doctoral fellowship at the University of Wisconsin. In 1978, he joined the faculty of the Department of Medicinal Chemistry in the College of Pharmacy at the University of Utah. Milt joined Eli Lilly and Company in 1983. While at Lilly, he has worked in natural products discovery and chemical research and development. Currently, he is a Senior Research Scientist in Technical Services for biosynthetic human insulin manufacturing. Milt has also served as a Guest Faculty member of the Chemistry Department at the University of Notre Dame and is currently an Industrial Advisory Board member for the Center for Bioprocessing and Biocatalysis, a research institute associated with the University of Iowa.
 
 

Updated 21 October 1998 by cinacs@www.che.uc.edu