Meeting Summary Hotel Information Program Prgm Book-7.5Mb Contacts 2003 Logo Call For Papers Submit Abstract Review Abstracts Registration Local Attractions Exhibitor Info Exhibitors Roomates Wanted Student Travel ACA Homepage	Exhibitors ACCELRYS, #100 9685 Scranton Road, San Diego, CA 92121 Tel: 858-799-5711 Fax: 858-799-5777 Email: bevb@accelrys.com Web: www.accelrys.com AREA DETECTOR SYSTEMS CORP, #201 12550 Stowe Drive, Poway, CA 92064 Tel: 858-486-0618 Fax: 858-486-0722 Email: sales@adsc-xray.com Web: www.adsc-xray.com CCD detector x-ray system for protein crystallography application. BLAKE INDUSTRIES, INC., #214 660 Jerusalem Road, Scotch Plains, NJ 07076 Tel: 908-233-7240 Fax: 908-233-1354 Email: blake4@xray.com Will be exhibiting Huber and Blake instruments and accessories for x-ray diffraction and crystallography with sealed tube, rotating anode or synchrotron. BRANDEL, #216 8561 Atlas Drive, Gaithersburg, MD 20877 Tel: 800-948-6506 Fax: 301-869-5570 Email: sales@brandel.com Web: www.brandel.com BRUKER AXS, #301 5465 E. Cheryl Parkway, Madison, WI 53711 Tel: 608-276-3000 Fax: 608-276-3006 Email: agrossen@bruker-axs.com Web: www.bruker-axs.com Provides advanced x-ray solutions in chemistry, life sciences and materials science. Small molecule APEX CCD systems feature highest sensitivity for all types of crystalline samples, including microcrystals and weak diffractors, and handle advanced research problems with twins, strong absorbers, charge density studies, modulated structures and diffuse scattering. Biological macromolecule PROTEUM systems feature the new high brilliance MICROSTAR and sensitive, large area CCDs for high-resolution data and high throughput screening at home. Synchrotron CCDs feature fast readout and a range of sizes. A new cryocooling device which generates its own nitrogen will be presented. Systems for combinatorial screening and SAXS highlight 2D fast readout, low noise detectors. CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE, #114 12 Union Rd., Cambridge United Kingdom, CB2 1EZ Tel: 44-1223-336408 Fax: 44-1223-336033 Email: lipscomb@ccdc.cam.ac.uk Web: www.ccdc.cam.ac.uk The CCDC collates and distributes the Cambridge Structural Database (CSD) which contains comprehensive crystal structure data for small organic and metal-organic compounds. The CSD system consists of the database itself, and accompanying software for search and retrieval ConQuest, structure visualization Mercury and statistical analysis Vista). The CCDC now also provides enCIFer for CIF editing and undertakes the development of the structural knowledge bases IsoStar and Mogul, plus a range of applications software - Gold for protein-ligand docking, SuperStar for predicting protein-ligand interactions, Relibase+ for easy searching of protein-ligand complexes and DASH for structure solution from powder diffraction data. CCP4 , #312A Daresbury Laboratory, Warrington, Cheshire,WA4 4AD United Kingdom Tel: 44-1925-603922 Fax: 44-1925-603825 Email: ccp4@ccp4.ac.uk Web: www.ccp4.ac.uk The Collaborative Computational Project No. 4 (CCP4) provides a software suite for macromolecular structure determination by X?ray crystallography used by academic institutions and commercial organizations around the world. Income form the project supports maintenance, distribution and development of the software, and funds additional activities including sponsorship of educational workshops, an annual Study Weekend, hosting e?mail discussion lists, and producing a bi?annual newsletter. CCP4 staff will be available to discuss any aspect of the project, including the latest release (5.0), the CCP4 molecular graphics program, the graphical user interface (CCP4i), and the data processing package MOSFLM. CORNING INCORPORATED, #215 45 Nagog Park, Acton, MA 01720 Tel: 978-635-2200 Fax: 978-635-2476 Email: clswebmail@corning.com Web: www.corning.com/lifesciences A leading manufacturer of high-quality, high performance consumables for the life science market. With expertise in surface chemistry, injection molding and material science, Corning offers plastic products to service the field of cell culture, liquid handling, filtration, genomics, and high throughput screening. At the show, Corning will be highlighting its 96 and 384 well protein crystallization plates. CRYO INDUSTRIES OF AMERICA, #302 11124 S. Willow Street, Manchester, NH 03103 Tel: 603-621-9957 Fax: 603-621-9960 Email: cryo@cryoindustries.com Web: www.cryoindustries.com Manufactures helium gas stream coolers that maintain the crystal at temperatures less than 10K! Now, a cryogen free version is available that provides a 15K temperature stream - no cryogens and a COLD 15K temperature. Single stream design minimizes turbulence, provides the longest laminar flow region and is easy to use. DATACENTRIC AUTOMATION, #106 2525 Perimeter Pl., Ste 131,Nashville, TN 37214 Tel: 625-263-9406 Fax: 625-263-9409 Email: lchlumsky@ne.rr.com Web: www.dcacorp.com DECODE GENETICS, #310 7869 NE Day Road West, Manchester, NH 03103 Tel: 206-780-8535 Fax: 206-780-8549 Email: csterling@decode.com Web: www.decode.com The Emerald Biostructures products from deCODE genetics provide structural solutions for biotechnology. The Emerald Screens provide the crystallographer cutting edge tools to do their science. With our complete RoboHTC platform, automating traditional bottlenecks, labs can increase reproducibility and throughput. DISCOVERY PARTNERS INTERNATIONAL, #306 9640 Towne Centre Drive, San Diego, CA 92121 Tel: 858-455-8600 Fax: 858-546-3083 Email: lmartonrana@discoverypartners.com Web: www.discoverypartners.com The Crystal Farm™ Imaging System is a modular, automated and integrated incubation and imaging system. Now you can control all incubation parameters, schedule plates for imaging, view and score images at your desk – all using your Web browser! Discovery Partners International is a Leader in Collaborative Drug Discovery. Through our proven capabilities in chemistry, biology, informatics, and computational modeling, customers gain ready access to everything needed to rapidly find and advance leads to development candidates. DIVERSIFIED SCIENTIFIC, #208 1601 12th Avenue South, Birmingham, AL 35205 Tel: 205-930-0001 Fax: 205-930-0082 Email: rglazer@dsitech.com Web: www.dsitech.com If you're looking to automate your protein crystallization experiments and have it seamlessly feed your bioinformatics database, DSI has the answers. Our patented CrystalScore™ is the first complete crystal imaging system, automatically acquiring, analyzing, and archiving your crystallization experiments. ScreenPro™ automatically sets up screens and optimizations. ScreenPro™ is an intelligent interface for your robot to give you easy screen setup and even easier optimizations, either stand-alone or working directly with CrystalScore™. DSI's newest division offers unique functional assays for drug discovery using our novel HuBio Assay™, incorporating our new HuBiogel™ biomatrix. DOUGLAS INSTRUMENTS, #116 Douglas House, East Garston, Hungerford, Berkshire, R917 7HD, United Kingdom Tel: 44-1488-649090 Fax: 44-1488-648975 Email: annemarie@douglas.co.uk Web: www.douglas.co.uk Designs and manufactures the IMPAX 1-5 and Oryx 1-6 systems for automatic protein crystallization. Both systems are mainly designed to carry out crystallization by the microbatch method, although Oryx 1-6 can also perform crystallization by vapor diffusion. Microbatch has many advantages including greater speed – and also the fact that it is truly micro – and consequently uses less protein. Recent studies have shown that microbatch finds a comparable or (in one case) a much greater number of hits than vapor diffusion in screening experiments. The company also makes miniaturized plates especially for crystallization by both vapor diffusion and microbatch. FLUIDIGM CORPORATION, #319 7100 Shortline Ct, So San Francisco, CA 94080 Tel: 650-266-6014 Fax: 650-871-7152 Email: jamie.bartels@fluidigm.com Web: www.fluidigm.com The Topaz Crystallizer enables a different approach to crystallization studies. By redefining and combining crystallization techniques in a microfluidic environment, the Crystallizer enables a new way to sample phase space and thus produces novel hits. The key component of the system is the Microprocessor, a microfluidic chip with integrated valves for precise fluid control. After the reagents and protein are dispensed, the Microprocessor uses these valves to allocate fluids into 3 predefined ratios. Each Microprocessor screens 48 reagents at 3 concentration ratios against a protein sample for a total of 144 unique conditions. With the Topaz Crystallizer, it is possible to screen, in parallel, over 5000 unique conditions with only 120 microliters of protein sample. FORMULATRIX, INC., #117 230 Third Avenue, Waltham, MA 02451 Tel: 781-466-6969 Fax: 509-561-5931 Email: farhana@formulatrix.com Web: www.formulatrix.com Has announced Rock Maker, a software solution for automating protein crystallization. Rock Maker automates and tracks the entire protein crystallization process including experiment design, liquid dispensing, plate storage and retrieval, and imaging. Designed to be platform independent, Rock Maker can be integrated with virtually any liquid dispensing, plate storage and retrieval, or imaging system. Formulatrix will provide you with a complete end-to-end solution by helping you choose the right robotics to meet your needs or integrating with existing robots that you already own. Rock Maker is a scalable, multi-user solution that can grow with your needs — scale from a single user solution with no automation up to a multi-user, multi-robot solution with complete automation. GENOMIC SOLUTIONS, #213 17851 Sky Park Circle, Irvine, CA 92887 Tel: 949-440-3680 Fax: 949-622-0255 Email: barbara.mcintosh@genomicsolutions.com Web: www.genomicsolutions.com Automated Honeybee Protein Crystallization System: Honeybee systems are designed with components to support protein crystallization experiments. Proprietary synQUAD allows fast, non contact dispense of both mother liquor and proteins. Dispense "on the fly" or in "step and repeat mode". Honeybee Systems are designed to support Microbatch, Sitting Drop, Hanging Drop, and Combinatorial Dispense applications. Hummingbird Technology: Hummingbird Systems provide fast, highly parallel non contact dispensing and transfer of compounds. The proprietary Hummingbird involves sipping of sample from a source plate using narrow-bore glass capillaries. Transfer occurs by aspirating sample using capillary action followed by dispensing with a pulse of air. Hummingbird cassettes hold 96 or 384 capillaries in a format to fit standard plates Cartesian Pipettor: The Cartesian Pipettor provide non Contact dispense via air displacement technology. Transfer up to 550 uL from a deep well plate to crystal plates with a simple GUI interface. GILSON, INC. , #207 3000 West Beltline Hwy, Middleton, WI 53562 Tel: 608-828-3252 Fax: 608-831-4451 Email: swagner@gilson.com Web: www.gilson.com A leading manufacturer of protein crystallography instrumentation for the pharmaceutical and biotechnology industries. With Gilson innovations, the process of preparing crystals is faster and easier than ever before. Gilson’s 925 PC Workstation automates the preparation of protein crystallography experiments in minutes and is designed for high-throughput screening for hanging, sitting, and microbatch crystallography. This versatile workstation accepts many types of crystallography plates, including Greiner™, Neuro Probe™, Corning™, and Intelli-Plate. Gilson’s range of systems work with 96- or standard 24-well formats, providing the ideal instruments to fit a variety of needs. Flexibility, reliability, and performance make these workstations invaluable tools for creating diffraction-quality crystals. GREINER BIO-ONE, #116A 1205 Sarah Street, Longwood, FL 32750 Tel: 407-333-2800 Fax: 407-333-3001 Email: ladams@greinerbiooneinc.com Web: www.greinerbioone.com Will feature novel products for microbatch, hanging-drop and sitting-drop techniques. Our ComboPlate™ is a universal 24 well, polystyrene plate designed to SBS standards. An 18 mm glass or plastic cover slip effectively seals each greased well for hanging drop applications. GREINER now offers Micro-Bridges that fit neatly into the wells of ComboPlate for sitting drop crystallization, and the bridges can be easily transferred to other wells during or after a crystallization experiment. Our CrystalQuick™ microplate enables simultaneous hanging and sitting drop vapor diffusion screens. New round sample wells eliminate wicking, while promoting optimal crystal growth. Greiner Bio-One has been manufacturing high purity, exceptional quality, laboratory plastics for over 35 years. HAMILTON COMPANY, #110 4970 Energy Way, Reno, NV 89502 Tel: 775-858-3000 Fax: 775-856-7259 Email: cvanderziel@hamiltoncompany.com Web: www.hamiltoncompany.com HAMPTON RESEARCH, #220 27632 El Lazo Road, Suite 100, Laguna Niguel, CA 92677 Tel: 949-425-1321 Fax: 949-425-1611 Email: info@hrmail.com Web: www.hamptonresearch.com Crystallization research tools and solutions for crystal growth. What’s new? CrystalCap magnetic with 2D bar code, greased 24 and 48 well VDX plate in microplate footprints with 12 and 18 mm siliconized cover slides. Plastic circle and square cover slides, crystallization grade agarose, SaltRx crystallization screen, FluorInert, and more. Please stop by, say hello, and check out the new stuff. HEWLETT PACKARD, #314 200 Forest Street, Marlboro, MA 01752 Tel: 508-467-3030 Fax: 508-467-5836 Email: angela.loh@hp.com Web: www.hp.com Committed to the life and materials sciences, working with leading crystallographic software developers to provide the research community with a range of affordable crystallographic solutions. HP delivers reliable, high performance Alpha and Intel® workstations and servers, an adaptive storage infrastructure of StorageWorks that accommodates multiple terabytes of data, and a wide offering of services from integration to support and management. For the latest, come visit the HP booth. INTERNATIONAL UNION OF CRYSTALLOGRAPHY, #117A PO Box 951, Chester, Cheshire, CH2 2WA United Kingdom Tel: 44-1244-376386 Fax: 44-1244-373675 Email: as@iucr.org Web: www.iucr.org The Crystallography Journals Online service (journals.iucr.org) offers full-text access to all IUCr journal articles from 1948 onwards. Visit the IUCr stand to experience this essential resource, including a new advanced search facility, and take advantage of our special offer to new personal subscribers. Try out the IUCr's first themed CD-ROM, "Selected papers on X-ray diffraction physics"; examine the latest editions of International Tables for Crystallography and preview those in preparation; and add or update your entry in the World Directory of Crystallographers. MAR USA, INC., #219 1880 Oak Avenue, Evanston, IL 60201 Tel: 847-869-1548 Fax: 847-869-1587 Email: cram@mar-usa.com Web: www.mar-usa.com Develops, markets and supports state-of-the-art x-ray instrumentation for protein crystallography and other x-ray diffraction applications, including imaging plate and CCD instruments for synchrotron and rotating anode x-ray sources. The marCCD, mosaic marCCD, mar345 imaging plate and the marCAM are all on display at our ACA booth. The new mar automated sample changer and the mar “desktop beamline” will be shown in action. Our instrumentation and software developers will be available to discuss your specific application. MICROCAL, #312 22 Industrial Drive East, Northampton, MA 01060 Tel: 413-586-7720 Fax: 413-486-0149 Email: pboynton@microcalorimetry.com Web: www.microcalorimetry.com MicroCal manufactures ultrasensitive VP-Isothermal Titration and Differential Scanning Calorimeters which are capable of rapidly characterizing binding and structural properties of biomolecules in highly automated, easy-to-perform experiments. The VP series represents major advances in sensitivity, reproducibility and stability, which translates into smaller sample requirements and greater precision. MOLECULAR DIMENSIONS, #115 Unit 4, Northfield Business Park, Northfield Road, Soham, Cambs, CB7 5UE Tel: 44-1353-722177 Fax: 44-1353-722119 Email; tony@moleculardimensions.com Web: www.moleculardimensions.com Supplies innovative protein crystal growth screens developed within our customers' laboratories as well as plates, coverslides, and protein expression media including SeMet. Molecular Dimensions sells the only cooled incubators specifically designed for crystal growth. With ± 0.5° C accuracy from 0 - 50° C these incubators operate virtually vibration free. Now a new bench top, stackable model is available to compliment the popular 6.36, 8.83 & 13.77 cubic foot range. At ACA 2003 Molecular Dimensions will introduce mosquitoT the ideal liquid handling tool for setting up protein crystallisation drops in high throughput screening plates. MXISYSTEMS, INC., #104 3401 West End Ave, Ste 500, Nashville TN 37203 Tel: 615-250-1975 Fax: 615-250-1677 Email; howard.motter@mxisystems.com Web: www.mxisystems.com Has developed a tabletop, pulsed, tunable, monochromatic x-ray source. The system offers scientists a convienient, practical alternative to synchrotrons without having to leave their home lab. The MX200 has been designed for protein crystallography and has the ability to vary the x-ray energy and brightness, to perform Laue scattering and MAD experiments. It produces a bright source of x-rays with a narrow divergence angle and is comparable to synchrotrons in flux, speed, and utility. NEXTAL BIOTECHNOLOGIES, #109 1751 Richardson, Suite 6101 Montreal, Quebec, H3K 1G6 Canada Tel: 514-849-8057 Fax: 514-849-4588 Email: mcmarchand@nextalbiotech.com Web: www.nextalbiotech.com Provides products designed specifically for the experimental needs of protein crystallization. Our innovative plates have independent screwable crystallization supports that are grease free, facilitating new experimental strategies. New, Nextal is also offering the first all-in-one pre-filled crystallization plate. We provide you with a fast and easy set-up; fresh conditions every time and increased reproducibility. Protein is all you need! OSMIC, INC. , #101 1900 Taylor Road, Auburn Hills, MI 48326 Tel: 248-232-6400 Fax: 248-232-6500 Email: sales@osmic.com Web: www.osmic.com Originator of graded multilayer x-ray optics for x-ray diffraction offers a full product line - Come see what's new! Confocal Max-Flux® Optics provide high flux and controlled divergence for single-crystal, SAXS, high-pressure and other diffraction applications. Micro Max® and MolyMax™ generators create high-flux, low-divergence beams offering rotating-anode-like performance from a sealed tube source - applications include protein crystallography, small molecule diffraction and SAXS. Max-Flux® parallel-beam optic upgrades are available for all x-ray diffractometers. Also offering a full range of Ovonyx™ multilayer analyzers for WDXRF spectrometry. OXFORD CRYOSYSTEMS, #211 220 Wood Road, Braintree, MA 02184 Tel: 781-843-5900 Fax: 781-843-5945 Email: l.quakenbush@oxcryo.ferrarisgroup.com Web: www.oxfordcryosystems.com Started manufacturing the original Cryostream Cooler in 1985 but still leads the field in cryostat design. This year we integrated the Cryoshutter, and innovative stream deflector for flash freezing and annealing, into the 700 series. The company also produces the HeliX, an open flow cryostat, using helium gas to reach temperatures as low as 28K and the Phenix, a revolutionary 11K helium cryostat for powder diffraction. Other products include the Metripol, a birefringence imaging system for quantifying strain and/or order in samples. Cryoaccessories and a software suite, Crystallographica, incorporating Crystallographica Search Match (CSM), both of which can be downloaded for free trial periods at www.crystallographica.com OXFORD DIFFRACTION, #218 130A Baker Avenue, Concord, MA 01742 Tel: 978-371-5506 Fax: 978-369-8287 Email: leigh.rees@oxford-diffraction.com Web: www.oxford-diffraction.com OXFORD INSTRUMENTS , #216A 130A Baker Avenue, Concord, MA 01742 Tel: 978-369-9933 Fax: 978-371-0204 Email: info@ma.oxinst.com Web: : www.oxford-instruments.com PROTEIN CRYSTALLOGRAPHY.COM, #121 Technology Networks, Crestland House, Acton, Sudbury, Suffolk, C010 08D United Kingdom Tel: 44-1787-319234 Fax: 44-1787-319235 Email: kbrowne@technologynetworks.net Web: www.proteincrystallography.com ProteinCrystallography.com is the new information portal for structural genomics and protein structure technologies. Featuring dedicated company, event and new product news it aims to keep researchers and business leaders up to date on what's happening in this important sector. A detailed Company Index makes finding specialist products and services easy. For reference there are links to research centres, relevant journals, books, papers, conference reviews and a discussion forum to discuss topical issues. Market reports are available in an online catalog and jobs can be advertised inexpensively. PROTEIN DATA BANK, #112 Department of Chemistry, Rutgers University 610 Taylor Road, Piscataway, NJ 08854 Tel: 732-445-0103 Fax: 732-445-4320 Email: info@rcsb.org Web: www.pdb.org The international resource for the processing and distribution of 3D macromolecular structure stat primarily determined experimentally by x-ray crystallography and NMR. RIGAKU, #101 9009 New Trail Drive, The Woodlands, TX 77381 Tel: 281-363-1033 Fax: 281-364-3628 Email: info@rigakumsc.com Web: www.rigakumsc.com Redefining the home lab as the world's leading resource for single-crystal X-ray diffraction hardware, software and contract services. Rigaku/MSC offers fully integrated small and macromolecule applications, Rigaku generators, X-ray optical systems, cryo-cooling devices and peripheral devices. In addition, Rigaku/MSC provides small and macromolecular structure determination services on a contract basis. ROBODESIGN INTERNATIONAL, #118 5920 Pasteur Court, Carlsbad, CA 92008 Tel: 760-438-5282 Fax: 760-438-5286 Email: tommyb@robodesign.com Web: www.robodesign.com The RoboMicroScope II, by RoboDesign International, Inc. is a fully integrated and automated system for protein crystal storage, inspection, and analysis. The key components of the system are the automated plate storage, retrieval, and incubation, image capture, automatic classification, and data viewing and management. CrystalTrak is a database solution ties all the data together by capturing and correlating plate setup conditions with the image scores. This data can then be used to optimize the next crystallization experiment. The RoboMicroscope II is a completely walk-away, modular system that introduces a level of consistency and throughput not currently possible with manual methods of protein crystal analysis. SOUTHEAST REGIONAL COLLABORATIVE ACCESS TEAM (SERCAT), #119 Univ. of Georgia, Biochemistry & MolecularBiology B202A Life Sciences Bldg, Athens, GA 30602 Tel: 706-542-3384 Fax: 706-542-3077 Email: kmorris@bc14.bmb.uga.edu Web: www.ser-cat.org The Southeast Regional Collaborative Access Team (SER-CAT) was formed in 1997 by 22 participating institutions to provide third generation X-ray capabilities to macromolecular crystallographers and structural biologists in the Southeast and Midwest. Its facilities, which are nearly complete, are located at Sector 22 of the Advanced Photon Source of the Argonne National Laboratory and consist of both an ID and BM beamline. SER-CAT's primary interest is serving its membership with the most advanced data collection facilities for macromolecular crystallography. Membership information is available at www.ser-cat.org or by contacting Kathy Morris at 706-542-3384. TECAN, #300 4022 Stirrup Creek Drive, Suite 310 Durham, NC 97703 Tel: 919-361-5200 Fax: 919-361-5201 Email: michelevalenta@tecan.com Web: www.tecan.com A leading provider of world-class automated liquid handling and laboratory robotic systems for over 23 years, offers the Protein Crystallization Workstation (PCW), a fully automated solution for high performance protein crystal growth and screening studies. Automated applications include custom buffer creation and highly-parallel set-up of sitting drop, hanging drop (new!) and microbatch experiments. Features such as low-vibration incubators, dynamic anti-evaporation cover and a high-precision liquid handling arm help insure high-quality crystal formation. Integrated image capture and analysis systems enable real-time monitoring of crystal growth. User-friendly software allows simplified experimental set-up, with novel CrysTool converter for creation of multi-parametric worklists. TRITEK CORP, #111 5263 Stewart Road, Sumerduck, VA 22742 Tel: 540-439-3690 Fax: 540-439-4009 Email: angie@tritekcorp.com Web: www.proteincrystalimaging.com CrystalPro is a fully integrated, computer controlled, high through-put, variable zoom microscopy system designed for detecting tiny crystals in large fields of view. Unique software enables the CrystalPro to auto-scan each well while capturing images, with annotation and time/date stamp, at a rate of 768 wells per hour. Customized program options include crystal discrimination and image analysis. VEECO INSTRUMENTS , #211A 2650 East Elvira Road, Tucson, AZ 85706 Tel: 520-741-1044 Fax: 520-294-1799 Email: info@veeco.com Web: www.veeco.com Large-scale protein crystallization efforts require fast, reliable screening of thousands of potentially crystal-producing experiments. The OASIS 1750 automatically locates, characterizes and scores protein crystal growth, providing rapid inspection of more than 8000 wells per hour. High-speed auto-focus and patent-pending illumination ensure eliable crystal detection and classification.